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Description. The present invention relates to improved processes for the preparation of orlistat, which is N-formyl-L-leucine derivative, in high purity. Orlistat, a tetrahydrolipstatin, is a useful pancreatic lipase-inhibiting agent and can be used for the prevention and treatment of obesity and hyperlipaemia.
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US-6734314-B2 chemical patent summary.
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US 8,680,298 B2 3 In general, amino orlistat may be obtained by deprotecting a protected amino orlistat. The Pivaloyl Formic Anhydride may be obtained by react
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A method to effectively treat the adverse events of ingested orlistat, and to maintain the effectiveness of ingested orlistat, the method comprising the steps of: ingesting a compound of orlistat to irreversibly bind with lipase enzymes of the gastrointestinal tract; ingesting a compound of simethicone to cause undigested fats to remain in an emulsified state in the bowel; and ingesting an.
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Orlistat is a medication used in the management of obesity. Orlistat acts by reversibly inhibiting gastric and pancreatic lipases. The inactivation of lipases prevents the hydrolysis of triglycerides, and thus free fatty acids are not absorbed. The maximum benefit of orlistat occurs when used in conjunction with diet and exercise. This activity reviews the indications, actions, and.
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Orlistat (marketed as Alli and Xenical) Information. Xenical (orlistat 120mg) was approved as a prescription product by FDA in 1999 for obesity management in conjunction with a reduced caloric.
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A stable pharmaceutical composition comprising dispersion blend comprising 20 to 60% by weight of orlistat and 40% to 80% by weight of water soluble polymer carrier selected from hydroxypropyl methyl cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose or hydroxypropyl methylcellulose and the like.
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Konsumsi orlistat dengan makanan yang tinggi lemak dapat meningkatkan risiko terjadinya efek samping. Orlistat dapat menghambat penyerapan vitamin yang larut dalam lemak, yaitu vitamin A, D, E, K. Jika Anda ingin mengonsumsi suplemen untuk memenuhi kebutuhan vitamin ini, jangan mengonsumsinya bersamaan dengan orlistat.
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Orlistat, sold under the brand name Xenical among others, is a medication used to treat obesity.Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.. Orlistat is the saturated derivative of lipstatin, a.
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XENICAL and ALLI products are used in the treatment of obesity management, including weight loss and weight maintenance, when used in conjunction with a reduced-calorie diet. The products are also indicated to reduce the risk for weight regain after prior weight loss. Orlistat is disclosed in U.S. Patent No: 4,598,089.
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WO2008149321A3 PCT/IB2008/052242 IB2008052242W WO2008149321A3 WO 2008149321 A3 WO2008149321 A3 WO 2008149321A3 IB 2008052242 W IB2008052242 W IB 2008052242W WO 2008149321 A3 WO2008149321 A3 WO 2008149321A3 Authority WO WIPO (PCT) Prior art keywords orlistat preparation pfa provides present Prior art date 2007-06-06 Application number PCT/IB2008/052242
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Abstract. A stable pharmaceutical composition comprising dispersion blend comprising 20 to 60% by weight of orlistat and 40% to 80% by weight of water soluble polymer carrier selected from hydroxypropyl methyl cellulose, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose or hydroxypropyl methylcellulose and the like.
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Deskripsi. ORLISTAT 120 MG merupakan obat yang mengandung orlistat. Orlistat digunakan bersama makanan rendah kalori, sebagai terapi tambahan pada pasien obesitas dengan Index Massa Tubuh (Body Mass Index/BMI) 30 kg/m2 dan diatasnya atau pasien yang berkelebihan berat badan dengan BMI 27 kg/m2 dan diatasnya yang memiliki faktor risiko terkait.
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Orlistat is a medicine that can help you to lose weight if you are obese or overweight. It works by interfering with the way fat is digested and absorbed by your body. It prevents the action of enzymes found in the digestive juices of your stomach and small intestine. These enzymes normally break down the fat which you consume in your diet.
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Orlistat side effects. Get emergency medical help if you have signs of an allergic reaction to orlistat: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using orlistat and call your doctor at once if you have: severe stomach pain; severe pain in your lower back; blood in your urine, painful or difficult urination;
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The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from.